Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium

XZ Kong; SR Mathias; T Guadalupe; C Abé; I Agartz; TN Akudjedu; A Aleman; S Alhusaini; NB Allen; D Ames; OA Andreassen; AA Vasquez; NJ Armstrong; F Bergo; ME Bastin; A Batalla; J Bauer; BT Baune; R Baur-Streubel; J Biederman; SK Blaine; P Boedhoe; E Bøen; A Bose; J Bralten; D Brandeis; S Brem; H Brodaty; D Yüksel; SJ Brooks; J Buitelaar; C Bürger; R Bülow; V Calhoun; A Calvo; EJ Canales-Rodríguez; JM Canive; DM Cannon; EC Caparelli; FX Castellanos; GL Cavalleri; F Cendes; TM Chaim-Avancini; K Chantiluke; QL Chen; X Chen; Y Cheng; A Christakou; VP Clark; D Coghill; CG Connolly; A Conzelmann; A Córdova-Palomera; J Cousijn; T Crow; A Cubillo; A Dale; U Dannlowski; SA De Bruttopilo; P De Zeeuw; IJ Deary; N Delanty; DV Demeter; A Di Martino; EW Dickie; B Dietsche; NT Doan; CP Doherty; A Doyle; S Durston; E Earl; S Ehrlich; CJ Ekman; T Elvsåshagen; JN Epstein; DA Fair; SV Faraone; G Fernández; GB Filho; K Förster; JP Fouche; JJ Foxe; T Frodl; P Fuentes-Claramonte; J Fullerton; H Garavan; DDS Garcia; IH Gotlib; AE Goudriaan; HJ Grabe; NA Groenewold; D Grotegerd; O Gruber; T Gurholt; J Haavik; T Hahn; NK Hansell; MA Harris; CA Hartman; MDCV Hernández

Journal article

Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium

XZ Kong, SR Mathias, T Guadalupe, C Abé, I Agartz, TN Akudjedu, A Aleman, S Alhusaini, NB Allen, D Ames, OA Andreassen, AA Vasquez, NJ Armstrong, F Bergo, ME Bastin, A Batalla, J Bauer, BT Baune, R Baur-Streubel, J Biederman Show all

Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2018

DOI: 10.1073/pnas.1718418115

Abstract

Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical t..

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University of Melbourne Researchers

Nick Allen Author

David Ames Author

Bernhard Baune Author

Dave Coghill Author

Related Projects (1)

ENIGMA-SD: Understanding sex differences in global mental health

Grants

Awarded by UK Research and Innovation

Funding Acknowledgements

B. F. received educational speaking fees from Merz and Shire. Some ENIGMA members listed in SI Appendix also declare a conflict of interest. The other authors declare no conflict of interest.